PUBLICATIONS
New book:
Storz, J. F. 2019. Hemoglobin: Insights into Protein Structure, Function, and Evolution. Oxford University Press (ISBN-9780198810681)
2024
Bautista, N. M., N. D. Herrera, E. Shadowitz, O. H. Wearing, Z. A. Cheviron, G. R. Scott, and J. F. Storz. 2024. Local adaptation, plasticity, and evolved resistance to hypoxic cold stress in high-altitude deer mice. Proceedings of the National Academy of Sciences USA 121: e2412526121.
Liang, X., Q. Duan, B. Li, Y. Wang, Y. Bu, Y. Zhang, Z. Kuang, L. Mao, X. An., H. Wang, X. Yang, N. Wan, Z. Feng, W. Shen, W. Miao, J. Chen, S. Liu, J. F. Storz, J. Liu, E. Nevo, and K. Li. 2024. Genomic structural variation contributes to evolved changes in gene expression in high-altitude Tibetan sheep. Proceedings of the National Academy of Sciences USA, 121: e2322291121.
An, X., L. Mao, Y. Wang, Q. Xu, X. Liu, S. Zhang, Z. Qiao, B. Li, F. Li, Z. Kuang, N. Wan, X. Liang, Q. Duan, Z. Feng, X. Yang, S. Liu, E. Nevo, J. Liu, J. F. Storz, and K. Li. 2024. Genomic structural variation is associated with hypoxia adaptation in high-altitude zokors. Nature Ecology and Evolution, 8: 339-351.
Storz, J. F., M. Quiroga-Carmona, S. Liphardt, N. D. Herrera, N. M. Bautista, J. C. Opazo, A. Rico-Cernhorska, J. Salazar-Bravo, J. M. Good, and G. D’Elía. 2024. Extreme high-elevation mammal surveys reveal unexpectedly high upper range limits of Andean mice. American Naturalist, 203: 726-735.
Storz, J. F., and G. R. Scott. 2024. To what extent do physiological tolerances determine elevational range limits of mammals? Journal of Physiology, 602: 5475-5484.
Takahashi, K., Y. Lee, A. Fago, N. M. Bautista, J. F. Storz, A. Kawamoto, G. Kurisu, T. Nishizawa, and J. R. H. Tame. 2024. The unique allosteric property of crocodilian haemoglobin revealed by cryo-EM. Nature Communications, 15: 6505.
Asim Khan, M., K. Yadev, A. V. Signore, N. Mittal, S. Uppal, A. K. Tyagi, G. Mittal, J. F. Storz, and S. Kundu. 2024. Hemoglobin β-F41K: a recombinant hemoglobin-based oxygen carrier prototype with engineered improvements in heme retention, thermal stability, and oxygenation properties. (in review)
Quezada-Romegialli, C., M. Quiroga-Carmona, G. D’Elía, C. Harrod, and J. F. Storz. 2024. Diet of Andean leaf-eared mice (Phyllotis) living at extreme elevations on Atacama volcanoes: insights from metagenomics, DNA metabarcoding, and stable isotopes. bioRxiv, doi.org/10.1101/2024.07.23.604871
Quiroga-Carmona, M., S. Liphardt, N. M. Bautista, P. Jayat, P. Teta, J. L. Malaney, T. McFarland, J. A. Cook, L. M. Blumer, N. D. Herrera, Z. A. Cheviron, J. M. Good, G. D’Elía, and J. F. Storz. 2024. Species limits and hybridization in Andean leaf-eared mice (Phyllotis). bioRxiv, doi.org/10.1101/2024.08.31.610610
2023
Natarajan, C., A. V. Signore, N. M. Bautista, F. G. Hoffmann, J. R. H. Tame, A. Fago, and J. F. Storz. 2023. Evolution and molecular basis of a novel allosteric property of crocodilian hemoglobin. Current Biology 33: 98-108.
Storz, J. F., S. Liphardt, M. Quiroga-Carmona, N. M. Bautista, J. C. Opazo, T. B. Wheeler, G. D’Elía, and J. M. Good. 2023. Genomic insights into the mystery of mouse mummies on the summits of Atacama volcanoes. Current Biology 33: R1040-1042.
Schweizer, R. M., C. M. Ivy, C. Natarajan, G. R. Scott, J. F. Storz, and Z. A. Cheviron. 2023. Gene regulatory changes underlie developmental plasticity in respiration and aerobic performance in highland deer mice. Molecular Ecology 32: 3483-3496.
Linck, E. B., J. L. Williamson, E. Bautista, E. J. Beckman, P. M. Benham, S. G. DuBay, L. M. Flores, C. R. Gadek, A. B. Johnson, M. R. Jones, J. Nuñez-Zapata, A. Quiñonez, C. J. Schmitt, D. Susanibar, J. Tiravanti C., K. Verde-Guerra, N. A. Wright, T. Valqui, J. F. Storz, and C. C. Witt. 2023. Blood variation implicates respiratory limits on elevational ranges of Andean birds. American Naturalist 201: 741-754.
Quiroga-Carmona, M., J. F. Storz, and G. D’Elía. 2023. Elevational range extension of the puna mouse, Punomys (Cricetidae), with the first record of the genus from Chile. Journal of Mammalogy 104: 1144-1151.
2022
Storz, J. F., and N. M. Bautista. 2022. Altitude-acclimatization, hemoglobin-oxygen affinity, and circulatory oxygen transport in hypoxia. Molecular Aspects of Medicine 84: 101052.
Chiou, K. L., M. C. Janiak, I. Schneider-Crease, S. Sen, F. Ayele, I. S. Chuma, S. Knauf, A. Lemma, A. V. Signore, A. M. D’Ippolito, B. Abebe, A. Azanaw Haile, F. Kebede, P. J. Fashing, N. Nguyen, C. McCann, M. L. Houck, J. D. Wall, A. S. Burrell, C. M. Bergey, J. Rogers, J. W. Phillips-Conroy, C. J. Jolly, A. D. Melin, J. F. Storz, A. Lu, J. C. Beehner, T. J. Bergman, N. Snyder-Mackler. 2022. Genomic signatures of high-altitude adaptation and chromosomal polymorphism in geladas. Nature Ecology and Evolution 6: 630-643.
Ivy, C. M., O. H. Wearing, C. Natarajan, R. M. Schweizer, N. Gutiérrez-Pinto, J. P. Velotta, S. C. Campbell-Staton, E. E. Petersen, A. Fago, Z. A. Cheviron, J. F. Storz, and G. R. Scott. 2022. Genetic variation in haemoglobin regulates breathing in high-altitude deer mice. Journal of Experimental Biology 225: jeb243595.
Steppan, S. J., T. Bowen, M. R. Bangs, M. Farson, J. F. Storz, M. Quiroga-Carmona, Guillermo D’Elía, L. Vimercati, C. Dorador Ortiz, G. Zimmerman, and S. K. Schmidt. 2022. Evidence of a population of leaf-eared mice (Phyllotis vaccarum) above 6,000 m in the Andes and a survey of high-elevation mammals. Journal of Mammalogy 103: 776-785.
Mohammadi, S., L. Yang, S. Herrera-Álvarez, M. del Pilar Rodríguez-Ordoñez, K. Zhang, J. F. Storz, S. Dobler, A. J. Crawford, and P. Andolfatto. 2022. Constraints on the evolution of toxin-resistant Na+,K+-ATPases have limited dependence on sequence divergence. PLoS Genetics 18: e1010323.
Mohammadi, S., H. I. Özdemir, P. Ozbek, F. Sumbul, J. Stiller, Y. Deng, A. J. Crawford, H. M. Rowland, J. F. Storz, P. Andolfatto, and S. Dobler. 2022. Epistatic effects between amino acid insertions and substitutions mediate toxin-resistance of vertebrate Na+,K+-ATPases. Molecular Biology and Evolution 39: msac258.
Yu, J. J., A. L. Non, E. C. Heinrich, W. Gu, J. Alcock, E. A. Moya, E. S. Lawrence, M. S. Tift, K. A.O’Brien, J. F. Storz, et al. (+ 30 other authors). 2022. Time domains of hypoxia responses and -omics insights. Frontiers in Physiology 13: 885295.
2021
Signore, A. V., M. S. Tift, F. G. Hoffmann, T. L. Schmitt, H. Moriyama, and . 2021. Evolved increases in hemoglobin-oxygen affinity and Bohr effect coincided with the aquatic specialization of penguins. Proceedings of the National Academy of Sciences USA 18: e2023936118
Mohammadi, S., L. Yang, A. Harpak, S. Herrera-Álvarez, M. Rodríguez-Ordoñez, J. Peng, K. Zhang, J. F. Storz, S. Dobler, A. Crawford, and P. Andolfatto. 2021. Concerted evolution reveals co-adapted amino acid substitutions in Na+K+-ATPase of frogs that prey on toxic toads. Current Biology 31: 2530-2538.
Schweizer, R. M., M. R. Jones, G. S. Bradburd, J. F. Storz, N. R. Senner, C. Wolf, and Z. A. Cheviron. 2021. Broad concordance in the spatial distribution of adaptive and neutral variation across an elevational gradient in deer mice. Molecular Biology and Evolution 38: 4286-4300.
Gutiérrez-Pinto, N., G. A. Londono, M. A. Chappell, and J. F. Storz. 2021. A test of altitude-related variation in aerobic metabolism of Andean birds. Journal of Experimental Biology 224: jeb237990.
Bautista, N. M., H. Malte, C. Natarajan, T. Wang, J. F. Storz, and A. Fago. 2021. New insights into the allosteric effects of CO2 and bicarbonate on crocodilian hemoglobin. Journal of Experimental Biology 224: jeb242615.
Bautista, N. M., E. E. Petersen, R. J. Jensen, C. Natarajan, J. F. Storz, D. A. Crossley, and A. Fago. 2021. Changes in hemoglobin function and isoform expression during embryonic development in the American alligator, Alligator mississippiensis. American Journal of Physiology – Regulatory, Integrative, and Comparative Physiology 321: R869-R878.
Storz, J. F., and A. V. Signore. 2021. Introgressive hybridization and hypoxia adaptation in high-altitude vertebrates. Frontiers in Genetics 12: 696484.
Wearing, O. H., C. M. Ivy, N. Gutierrez-Pinto, J. P. Velotta, S. C. Campbell-Staton, C. Natarajan, Z. A. Cheviron, J. F. Storz, and G. R. Scott. 2021. The adaptive benefit of increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice. BMC Biology 19: 128.
Hoffmann, F. G., J. F. Storz, S. Kuraku, M. Vandewege, and J. C. Opazo. 2021. Whole-genome duplications and the diversification of the Globin X genes of vertebrates. Genome Biology and Evolution 13: evab205.
2020
Pillai, A. S., S. A. Chandler, Y. Liu, A. V. Signore, C. R. Cortez-Romero, J. L. P. Benesch, A. Laganowsky, J. F. Storz, G. K. A. Hochberg, J. W. Thornton. 2020. Origin of complexity in haemoglobin evolution. Nature 581: 480-485. PDF
Signore, A. V., and J. F. Storz. 2020. Biochemical pedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope. Science Advances 6: eabb5447. PDF
Storz, J. F., M. Quiroga-Carmona, J. C. Opazo, T. Bowen, M. Farson, and G. D’Elía. 2020. Discovery of the world’s highest dwelling mammal. Proceedings of the National Academy of Sciences USA 117: 18169-18171. PDF
Tate, K. B., O. H. Wearing, C. M. Ivy, Z. A. Cheviron, J. F. Storz, G. B. McClelland, and G. R. Scott. Coordinated changes across the O2 transport pathway underlie adaptive increases in thermogenic capacity in high-altitude deer mice. Proceedings of the Royal Society of London B 287: 20192750. PDF
Ivy, C. M., M. A. Greaves, E. D. Sangster, C. E. Robertson, C. Natarajan, J. F. Storz, G. B. McClelland, and G. R. Scott. 2020. Ontogenesis of evolved changes in respiratory physiology in deer mice native to high altitude. Journal of Experimental Biology 223: jeb219360. PDF
Storz, J. F., C. Natarajan, M. K. Grouleff, M. Vandewege, F. G. Hoffmann, X. You, B. Venkatesh, and A. Fago. 2020. Oxygenation properties of hemoglobin and the evolutionary origins of isoform multiplicity in an amphibious air-breathing fish, the blue-spotted mudskipper (Boleophthalmus pectinirostris). Journal of Experimental Biology 223: jeb217307. PDF
Fago, A., C. Natarajan, M. Pettinati, F. G. Hoffmann, T. Wang, R. E. Weber, S. I. Drusin, F. Issoglio, M. A. Martí, D. A. Estrin, and J. F. Storz. 2020. Structure and function of crocodilian hemoglobins and allosteric regulation by chloride, ATP, and CO2. American Journal of Physiology – Regulatory, Integrative, and Comparative Physiology 318: R657-R667. PDF
Natarajan, C., A. V. Signore, V. Kumar, J. F. Storz. 2020. Synthesis of recombinant hemoglobin with NH2-terminal acetylation in Escherichia coli. Current Protocols in Protein Science 101: e112. doi: 10.1002/cpps.112.
Natarajan, C., A. V. Signore, V. Kumar, R. E. Weber, A. Fago, and J. F. Storz. 2020. Effect of NH2-terminal acetylation on the oxygenation properties of vertebrate hemoglobin. Biochemical Journal 477: 3839-3850.
Faber, J. E., J. F. Storz, Z. A. Cheviron, and H. Zhang. 2020. High-altitude rodents have abundant collaterals that protect against tissue injury after cerebral, coronary, and peripheral artery occlusion. Journal of Cerebral Blood Flow and Metabolism 41: 731-744.
Mahalingam, S., Z. A. Cheviron, J. F. Storz, G. B. McClelland, and G. R. Scott. 2020. Chronic cold exposure induces mitochondrial plasticity in deer mice native to high altitude. The Journal of Physiology 598: 5411-5426.
Prothmann, A., F. G. Hoffmann, J. C. Opazo, P. Herbener, J. F. Storz, T. Burmester, and T. Hankeln. 2020. The globin gene family in arthropods: evolution and functional diversity. Frontiers in Genetics 11: 858.
2019
Storz, J. F., and G. R. Scott. 2019. Life ascending: mechanism and process in physiological adaptation to high-altitude hypoxia. Annual Review of Ecology, Evolution, and Systematics 50: 503-526. PDF
Storz, J. F., Z. A. Cheviron, G. B. McClelland, and G. R. Scott. 2019. Physiological performance capacities and environmental adaptation: insights from high-elevation deer mice (Peromyscus maniculatus). Journal of Mammalogy 100: 910-922. PDF
Storz, J. F., C. Natarajan, C. C. Witt, D. M. McCandlish, and A. Stoltzfus. 2019. The role of mutation bias in adaptive molecular evolution: insights from convergent changes in protein function. Philosophical Transactions of the Royal Society B 374: 20180238. PDF
Signore, A. V., Y. -Z. Yang, Q. -Y. Yang, G. Qin, H. Moriyama, R. -L. Ge, and J. F. Storz. 2019. Adaptive changes in hemoglobin function in high-altitude Tibetan canids were derived via gene conversion and introgression. Molecular Biology and Evolution 36: 2227-2237. PDF
Schweizer, R. M., J. P. Velotta, C. M. Ivy, M. R. Jones, S. M. Muir, G. S. Bradburd, J. F. Storz, G. R. Scott, and Z. A. Cheviron. 2019. Physiological and genomic evidence that selection on the transcription factor Epas1 has altered cardiovascular function in high-altitude deer mice. PLoS Genetics 15: e1008420. PDF
2018
Natarajan C., A. Jendroszek, A. Kumar, R. E. Weber, J. R. H. Tame, A. Fago, and J. F. Storz. 2018. Molecular basis of hemoglobin adaptation in the high-flying bar-headed goose. PLoS Genetics e1007331. PDF [journal cover]
Zhu, X., Y. Guan, A. V. Signore, C. Natarajan, S. G. DuBay, Y. Cheng, N. Han, G. Song, Y. Qu, H. Moriyama, F. G. Hoffmann, A. Fago, F. Lei, and J. F. Storz. 2018. Divergent and parallel routes of biochemical adaptation in high-altitude passerine birds from the Qinghai-Tibet Plateau. Proceedings of the National Academy of Sciences USA 115: 1865-1870. PDF
Storz, J. F. 2018. Compensatory mutations and epistasis for protein function. Current Opinion in Structural Biology 50: 18-25. PDF
Hoffmann, F. G., M. W. Vandewege, J. F. Storz, and J. C. Opazo. 2018. Gene turnover and diversification of the α- and β-globin gene families in sauropsid vertebrates. Genome Biology and Evolution 10: 344-358. PDF
Jendroszek, A., H. Malte, C. B. Overgaard, R. E. Weber, K. Beedholm, C. Natarajan, J. F. Storz, and A. Fago. 2018. Allosteric mechanisms underlying the adaptive increase in hemoglobin-oxygen affinity of the bar-headed goose. Journal of Experimental Biology 221: Jeb.185470 (doi:10.1242/jeb.185470) PDF
2017
Storz, J. F., and G. B. McClelland. 2017. Rewiring metabolism under oxygen deprivation. Science 356: 248-249. PDF
Kumar, A., C. Natarajan, H. Moriyama, C. C. Witt, R. E. Weber, A. Fago, and J. F. Storz. 2017. Stability-mediated epistasis restricts accessible mutational pathways in the functional evolution of avian hemoglobin. Molecular Biology and Evolution 34: 1240-1251. PDF
Lau, D., A. Connaty, S. Mahalingam, N. Wall., Z. A. Cheviron, J. F. Storz, G. R. Scott, and G. B. McClelland. 2017. Acclimation to hypoxia increases carbohydrate use during exercise in high-altitude deer mice. American Journal of Physiology – Regulatory, Integrative, and Comparative Physiology 312: R400-R411. PDF
Tate, K. B., C. M. Ivy, J. P. Velotta, J. F. Storz, G. B. McClelland, Z. A. Cheviron, G. R. Scott. 2017. Circulatory mechanisms underlying adaptive increases in thermogenic capacity in high-altitude deer mice. Journal of Experimental Biology 220: 3616-3620. PDF
Inoguchi, N., N. Mizuno, S. Baba, T. Kumasaka, C. Natarajan, J. F. Storz, and H. Moriyama. 2017. Alteration of the α1β2/α1β2 subunit interface contributes to the increased hemoglobin-oxygen affinity of high-altitude deer mice. PLoS One 12: e0174921. PDF
2016
Natarajan, C., F. G. Hoffmann, R. E. Weber, A. Fago, C. C. Witt, and J. F. Storz. 2016. Predictable convergence in hemoglobin function has unpredictable molecular underpinnings. Science 354: 336-340. PDF [commentary by Bridgham] (selected by Faculty of 1000)
Storz, J. F. 2016. Causes of molecular convergence and parallelism in protein evolution. Nature Reviews Genetics 17: 239-250. PDF
Storz, J. F. 2016. Gene duplication and evolutionary innovations in hemoglobin-oxygen transport. Physiology 31: 223-232. PDF
Storz, J. F. 2016. Hemoglobin-oxygen affinity in high-altitude vertebrates: Is there evidence for an adaptive trend? Journal of Experimental Biology 219: 3190-3203. PDF
Storz, J. F., and Z. A. Cheviron. 2016. Functional genomic insights into regulatory mechanisms of high-altitude adaptation. Advances in Experimental Medicine and Biology 903: 113-128. PDF
Jensen, B., J. F. Storz, and A. Fago. 2016. Bohr effect and temperature sensitivity of hemoglobins from highland and lowland deer mice. Comparative Biochemistry and Physiology A: Molecular and Integrative Physiology 195: 10-14. PDF
2015
Galen, S. C., C. Natarajan, H. Moriyama, R. E. Weber, A. Fago, P. M. Benham, A. N. Chavez, Z. A. Cheviron, J. F. Storz, and C. C. Witt. 2015. Contribution of a mutational hot spot to hemoglobin adaptation in high-altitude Andean house wrens. Proceedings of the National Academy of Sciences USA 112: 13958-13963. PDF [commentary by Stoltzfus & McCandlish]
Natarajan, C., J. Projecto-Garcia, H. Moriyama, R. E. Weber, V. Munoz-Fuentes, A. J. Green, C. Kopuchian, P. L. Tubaro, L. Alza, M. Bulgarella, M. M. Smith, R. E. Wilson, A. Fago, K. G. McCracken, and J. F. Storz. 2015. Convergent evolution of hemoglobin function in high-altitude Andean waterfowl involves limited parallelism at the molecular sequence level. PLoS Genetics 11: e1005681. PDF
Tufts, D. M., C. Natarajan, I. G. Revsbech, J. Projecto-Garcia, F. G. Hoffmann, R. E. Weber, A. Fago, H. Moriyama, and J. F. Storz. 2015. Epistasis constrains mutational pathways of hemoglobin adaptation in high-altitude pikas. Molecular Biology and Evolution 32: 287-298. PDF
Opazo, J. C., F. G. Hoffmann, C. C. Witt, M. Berenbrink, and J. F. Storz. 2015. Gene turnover in the avian globin gene families and evolutionary changes in hemoglobin isoform expression. Molecular Biology and Evolution 32: 871-887. PDF
Natarajan, C., F. G. Hoffmann, H. C. Lanier, C. J. Wolf, Z. A. Cheviron, M. L. Spangler, R. E. Weber, A. Fago, and J. F. Storz. 2015. Intraspecific polymorphism, interspecific divergence, and the origins of function-altering mutations in deer mouse hemoglobin. Molecular Biology and Evolution 32: 978-997. PDF
Opazo, J. C., A. P. Lee, F. G. Hoffmann, J. Toloza-Villalobos, T. Burmester, B. Venkatesh, and J. F. Storz. 2015. Ancient duplications and expression divergence in the globin gene superfamily of vertebrates: Insights from the elephant shark genome and transcriptome. Molecular Biology and Evolution 32: 1684-1694. PDF
Scott, G. R., T. S. Elogio, M. A., Lui, J. F. Storz, and Z. A. Cheviron. 2015. Adaptive modifications of muscle phenotype in high-altitude deer mice are associated with evolved changes in gene regulation. Molecular Biology and Evolution 32: 1962-1976. PDF
Storz, J. F., J. T. Bridgham, S. A. Kelly, and T. Garland. 2015. Genetic approaches in comparative and evolutionary physiology. American Journal of Physiology – Regulatory, Integrative, and Comparative Physiology 309: R197-R214. PDF
Lui, M. A., S. Mahalingam, P. Patel, A. D. Connaty, C. M. Ivy, Z. A. Cheviron, J. F. Storz, G. B. McClelland, and G. R. Scott. 2015. High-altitude ancestry and hypoxia acclimation have distinct effects on exercise capacity and muscle phenotype in deer mice. American Journal of Physiology – Regulatory, Integrative, and Comparative Physiology 308: R779-R791. PDF
Storz, J. F., C. Natarajan, H. Moriyama, F. G. Hoffmann, T. Wang, A. Fago, H. Malte, J. Overgaard, and R. E. Weber. 2015. Oxygenation properties and isoform diversity of snake hemoglobins. American Journal of Physiology – Regulatory, Integrative, and Comparative Physiology 309: R1178-R1191. PDF
Janecka, J. E., S. S. E. Nielsen, S. D. Andersen, F. G. Hoffmann, R. E. Weber, T. Anderson, J. F. Storz, and A. Fago. 2015. Genetically-based low oxygen-affinities of felid hemoglobins: lack of biochemical adaptation to high-altitude hypoxia in the snow leopard. Journal of Experimental Biology 218: 2402-2409. PDF [JEB commentary]
2014
Zhang, G., C. Li, Q. Li, B. Li, D. M. Larkin, C. Lee, J. F. Storz, …F. G. Hoffmann, J. C. Opazo,…et al. (members of the avian genome consortium). 2014. Comparative genomics reveals insights into avian genome evolution and adaptation. Science 346: 1311-1320. PDF
Cheviron, Z. A., C. Natarajan, J. Projecto-Garcia, D. K. Eddy, J. Jones, M. D. Carling, C. C. Witt, H. Moriyama, R. E. Weber, A. Fago, and J. F. Storz. 2014. Integrating evolutionary and functional tests of adaptive hypotheses: a case study of altitudinal differentiation in hemoglobin function in an Andean sparrow, Zonotrichia capensis. Molecular Biology and Evolution 31: 2948-2962. PDF
Schwarze, K., K. L. Campbell, T. Hankeln, J. F. Storz, F. G. Hoffmann, and T. Burmester. 2014. The globin gene repertoire of lampreys: convergent evolution of hemoglobin and myoglobin in jawed and jawless vertebrates. Molecular Biology and Evolution 31: 2708-2721. PDF
Gaudry, M. J., J. F. Storz, G. T. Butts, K. L. Campbell, and F. G. Hoffmann. 2014. Repeated evolution of chimeric fusion genes in the β-globin gene family of laurasiatherian mammals. Genome Biology and Evolution 6: 1219-1233. PDF (selected by Faculty of 1000)
Cheviron, Z. A., A. D. Connaty, G. B. McClelland, and J. F. Storz. 2014. Functional genomics of adaptation to hypoxic cold-stress in high-altitude deer mice: transcriptomic plasticity and thermogenic performance. Evolution 68: 48-62. PDF (selected by Faculty of 1000)
2013
Natarajan, C., N. Inoguchi, R. E. Weber, A. Fago, H. Moriyama, and J. F. Storz. 2013. Epistasis among adaptive mutations in deer mouse hemoglobin. Science 340: 1324-1327. PDF [Perspective by E. Rezende] (selected by Faculty of 1000)
Projecto-Garcia, J., C. Natarajan, H. Moriyama, R. E. Weber, A. Fago, Z. A. Cheviron, R. Dudley, J. A. McGuire, C. C. Witt, and J. F. Storz. 2013. Repeated elevational transitions in hemoglobin function during the evolution of Andean hummingbirds. Proceedings of the National Academy of Sciences USA 110: 20669-20674. PDF
Revsbech, I., D. M. Tufts, J. Projecto-Garcia, H. Moriyama, R. E. Weber, J. F. Storz, and A. Fago. 2013. Hemoglobin function and allosteric regulation in semi-fossorial rodents (family Sciuridae) with different altitudinal ranges. Journal of Experimental Biology 216: 4264-4271. PDF [JEB cover] [JEB Commentary] (JEB ‘Outstanding Paper of 2013’)
Damsgaard, C., J. F. Storz, F. G. Hoffmann, and A. Fago. 2013. Hemoglobin isoform differentiation and allosteric regulation of oxygen binding in the turtle, Trachemys scripta. American Journal of Physiology – Regulatory, Integrative, and Comparative Physiology 305: R961-967. PDF
Weber, R. E, A. Fago, H. Malte, J. F. Storz, and T. A. Gorr. 2013. Lack of conventional oxygen-linked proton- and anion-binding sites does not impair allosteric regulation of oxygen binding in dwarf caiman hemoglobin. American Journal of Physiology – Regulatory, Integrative, and Comparative Physiology 305: R300-R312. PDF (selected by Faculty of 1000)
Inoguchi, N., J. Oshlo, C. Natarajan, R. E. Weber, A. Fago, J. F. Storz, and H. Moriyama. 2013. Deer mouse hemoglobin exhibits a lowered oxygen affinity owing to mobility of the E helix. Acta Crystallographica F69: 393-398. PDF
Cheviron, Z. A., G. C. Bachman, and J. F. Storz. 2013. Contributions of phenotypic plasticity to population differences in thermogenic performance between highland and lowland deer mice. Journal of Experimental Biology 216: 1160-1166. PDF [JEB cover]
![[JEB cover]](https://storzlab.unl.edu/wp-content/uploads/2015/02/JEB_cover_April_2013.gif){kind=link}
Tufts, D. M., I. Revsbech, Z. A. Cheviron, R. E. Weber, A. Fago, and J. F. Storz. 2013. Phenotypic plasticity in blood-oxygen transport in highland and lowland deer mice. Journal of Experimental Biology 216: 1167-1173. PDF [JEB cover]
Storz, J. F., J. C. Opazo, and F. G. Hoffmann. 2013. Gene duplication, genome duplication, and the functional diversification of vertebrate globins. Molecular Phylogenetics and Evolution 66: 469-478 (special issue – Morris Goodman tribute). PDF
Opazo, J. C., G. T. Butts, M. F. Nery, J. F. Storz, and F. G. Hoffmann. 2013. Whole-genome duplication and the functional diversification of teleost fish hemoglobins. Molecular Biology and Evolution 30: 140-153. PDF
2012
Cheviron, Z. A., G. C. Bachman, A. D. Connaty, G. B. McClelland, and J. F. Storz. 2012. Regulatory changes contribute to the adaptive enhancement of thermogenic capacity in high-altitude deer mice. Proceedings of the National Academy of Sciences USA, 109: 8635-8640. PDF (selected by Faculty of 1000)
Grispo, M. T., C. Natarajan, J. Projecto-Garcia, H. Moriyama, R. E. Weber, and J. F. Storz.2012. Gene duplication and the evolution of hemoglobin isoform differentiation in birds. Journal of Biological Chemistry 287: 37647-37658. PDF
Carey, H. V., S. L. Martin, B. A. Horowitz, L. Yan, S. M. Bailey, J. Podrabsky, J. F. Storz, R. M. Ortiz, R. P. Wong, and D. A. Lathrop. 2012. Elucidating nature’s solutions to heart, lung, and blood diseases and sleep disorders. Circulation Research, 110: 915-921. PDF
Hoffmann, F. G., J. C. Opazo, D. Hoogewijs, T. Hankeln, B. Ebner, S. Vinogradov, X. Bailly, and J. F. Storz. 2012. Evolution of the globin gene family in deuterostomes: lineage-specific patterns of diversification and attrition. Molecular Biology and Evolution, 29: 1735-1745. PDF
Hoogewijs, D., B. Ebner, F. Germani, F. G. Hoffmann, A. Fabrizius, L. Moens, T. Burmester, S. Dewilde, J. F. Storz, S. Vinogradov, and T. Hankeln. 2012. Androglobin: a chimeric globin in metazoans that is preferentially expressed in mammalian testes. Molecular Biology and Evolution, 29: 1105-1114. PDF
Hoffmann, F. G., J. C. Opazo, and J. F. Storz. 2012. Whole-genome duplications spurred the functional diversification of the globin gene superfamily in vertebrates. Molecular Biology and Evolution, 29: 303-312. PDF (selected by Faculty of 1000)
Storz, J. F., C. Natarajan, Z. A. Cheviron, F. G. Hoffmann, and J. K. Kelly. 2012. Altitudinal variation at duplicated β-globin genes in deer mice: effects of selection, recombination, and gene conversion. Genetics, 190: 203-216. PDF [Genetics cover]
Campos, R. A., J. F. Storz, and N. Ferrand. 2012. Copy number polymorphism in the α-globin gene cluster of the European rabbit (Oryctolagus cuniculus). Heredity, 108: 531-536. PDF
Storz, J. F., R. E. Weber, and A. Fago. 2012. Oxygenation properties and oxidation rates of mouse hemoglobins that differ in reactive cysteine content. Comparative Biochemistry and Physiology A: Molecular and Integrative Physiology, 161: 265-270. PDF
2011
Hoffmann, F. G., J. C. Opazo, and J. F. Storz. 2011. Differential loss and retention of myoglobin, cytoglobin, and globin-E during the radiation of vertebrates. Genome Biology and Evolution, 3: 588-600. PDF
Storz, J. F., J. C. Opazo, and F. G. Hoffmann. 2011. Phylogenetic diversification of the globin gene superfamily in chordates. IUBMB Life, 63: 313-322. PDF
Storz, J. F., and A. J. Zera. 2011. Experimental approaches for assessing the contributions of candidate protein-coding mutations to phenotypic evolution. Pp. 377-396 in Molecular methods for Evolutionary Genetics (Orgogozo, V., and M. V. Rockman, eds.). Humana Press (Springer): New York. PDF
Natarajan, C., X. Jiang, A. Fago, R. E. Weber, H. Moriyama, and J. F. Storz. 2011. Expression and purification of recombinant hemoglobin in Escherichia coli. PLoS ONE, 6: e20176. PDF
Storz, J. F., F. G. Hoffmann, J. C. Opazo, T. J. Sanger, and H. Moriyama. 2011. Developmental regulation of hemoglobin synthesis in the green anole lizard, Anolis carolinensis. Journal of Experimental Biology, 214: 575-581. PDF
Rytkonen, K. T., and J. F. Storz. 2011. Evolutionary origins of oxygen sensing in animals. EMBO Reports , 12: 3-4. PDF
2010
Hoffmann, F. G., J. C. Opazo, and J. F. Storz. 2010. Gene co-option and convergent evolution of oxygen-transport hemoglobins in jawed and jawless vertebrates. Proceedings of the National Academy of Sciences USA, 107: 14274-14279. PDF (selected by Faculty of 1000)
Storz, J. F., G. R. Scott, and Z. A. Cheviron. 2010. Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates. Journal of Experimental Biology, 213: 4125-4136. PDF [JEB cover]
Storz, J. F., A. M. Runck, H. Moriyama, R. E. Weber, and A. Fago. 2010. Genetic differences in hemoglobin function between highland and lowland deer mice. Journal of Experimental Biology, 213: 2565-2574. PDF [JEB cover]
Kakar, S., F. G. Hoffmann, J. F. Storz, M. Fabian, and M. S. Hargrove. 2010. Structure and reactivity of hexacoordinate hemoglobins. Biophysical Chemistry, 152: 1-14. PDF
Storz, J. F., and C. W. Wheat. 2010. Integrating evolutionary and functional approaches to infer adaptation at specific loci. Evolution, 64: 2489-2509. PDF
Storz, J. F. 2010. Genes for high altitudes. Science, 329: 40-41. PDF
Campbell, K. L., J. F. Storz, A. V. Signore, H. Moriyama, K. C. Catania, A. Payson, J. Bonaventura, J. Stetefeld, and R. E. Weber. 2010. Molecular basis of a novel adaptation to hypoxic hypercapnia in a strictly fossorial mole. BMC Evolutionary Biology, 10: 214. PDF (‘highly accessed’)
Runck, A. M., R. E. Weber, A. Fago, and J. F. Storz. 2010. Evolutionary and functional properties of a two-locus β-globin polymorphism in Indian house mice. Genetics, 184: 1121-1131. PDF
Hoffmann, F. G., J. F. Storz, T. A. Gorr, and J. C. Opazo. 2010. Lineage-specific patterns of functional diversification in the α- and β-globin gene families of tetrapod vertebrates. Molecular Biology and Evolution, 27: 1126-1138. PDF
2009
Storz, J. F., A. M. Runck, S. J. Sabatino, J. K. Kelly, N. Ferrand, H. Moriyama, R. E. Weber, and A. Fago. 2009. Evolutionary and functional insights into the mechanism underlying high altitude adaptation of deer mouse hemoglobin. Proceedings of the National Academy of Sciences USA, 106: 14450-14455. PDF (selected by Faculty of 1000)
Runck, A. M., H. Moriyama, and J. F. Storz. 2009. Evolution of duplicated β-globin genes and the structural basis of hemoglobin isoform differentiation in Mus. Molecular Biology and Evolution, 26: 2521-2532.PDF
Opazo, J. C, A. Sloan, K. L. Campbell, and J. F. Storz. 2009. Origin and ascendancy of a chimeric fusion gene: the β/δ-globin gene of paenungulate mammals. Molecular Biology and Evolution, 26: 1469-1478. PDF
Gering, E. J., J. C. Opazo, and J. F. Storz. 2009. Molecular evolution of cytochrome b in high- and low-altitude deer mice (genus Peromyscus). Heredity, 102: 226-235. PDF
Storz, J. F. 2009. Gene duplication and the resolution of adaptive conflict. Heredity, 102: 99-100. PDF
2008
Opazo, J. C, F. G. Hoffmann, and J. F. Storz. 2008. Differential loss of embryonic globin genes during the radiation of placental mammals. Proceedings of the National Academy of Sciences USA, 105: 12950-12955. PDF
Opazo, J. C, F. G. Hoffmann, and J. F. Storz. 2008. Genomic evidence for independent origins of β-like globin genes in monotremes and therian mammals. Proceedings of the National Academy of Sciences USA, 105: 1590-1595. PDF [JEB Commentary]
Storz, J. F., and J. K. Kelly. 2008. Effects of spatially varying selection on nucleotide diversity and linkage disequilibrium: Insights from deer mouse globin genes. Genetics, 180: 367-379. PDF (selected by Faculty of 1000)
Storz, J. F., F. G. Hoffmann, J. C. Opazo, and H. Moriyama. 2008. Adaptive functional divergence among triplicated α-globin genes in rodents. Genetics, 178: 1623-1638. PDF
Hoffmann, F. G., J. C. Opazo, and J. F. Storz. 2008. New genes originated via multiple recombinational pathways in the β-globin gene family of rodents. Molecular Biology and Evolution, 25: 2589-2600. PDF
Hoffmann, F. G., J. C. Opazo, and J. F. Storz. 2008. Rapid rates of lineage-specific gene duplication and deletion in the α-globin gene family. Molecular Biology and Evolution, 25: 591-602. PDF
Storz, J. F., and H. Moriyama. 2008. Mechanisms of hemoglobin adaptation to high-altitude hypoxia. High Altitude Medicine and Biology, 9: 148-157. PDF
Campos, R., J. F. Storz, and N. Ferrand. 2008. Evidence for contrasting modes of selection at interacting globin genes in the European rabbit. Heredity, 100: 602-609. PDF
2007
Storz, J. F., M. Baze, J. L. Waite, F. G. Hoffmann, J. C. Opazo, and J. P. Hayes. 2007. Complex signatures of selection and gene conversion in the duplicated globin genes of house mice. Genetics, 177: 481-500. PDF
F. G. Hoffmann, and J. F. Storz. 2007. The αD-globin gene originated via duplication of an embryonic α-like globin gene in the ancestor of tetrapod vertebrates. Molecular Biology and Evolution, 24: 1982-1990. PDF
Storz, J.F., S.J. Sabatino, F.G. Hoffmann, E.J. Gering, H. Moriyama, et al. 2007. The molecular basis of high-altitude adaptation in deer mice. PLoS Genetics, 3: e45, 0448-0459. PDF (selected by Faculty of 1000)
Storz, J. F. 2007. Hemoglobin function and physiological adaptation to hypoxia in high-altitude mammals. Journal of Mammalogy, 88: 24-31. PDF
Storz, J. F., and H. E. Hoekstra. 2007. The study of adaptation and speciation in the genomic era. Journal of Mammalogy, 88: 1-4. PDF
2006 and earlier
Storz, J. F., H. R. Bhat, J. Balasingh, P. T., Nathan, and T. H. Kunz. 2006. Evolutionary dynamics of the short-nosed fruit bat, Cynopterus sphinx (Pteropodidae): Inferences from the spatial scale of genetic and phenotypic differentiation. Pp. 248-268 in Functional and Evolutionary Ecology of Bats (Zubaid, A., G. F. McCracken, and T. H. Kunz, eds). Oxford University Press: New York.
Storz, J. F. 2005. Using genome scans of DNA polymorphism to infer adaptive population divergence. Molecular Ecology, 14: 671-688. PDF
Storz, J. F. 2005. Nonrandom dispersal and local adaptation. Heredity, 95: 3-4. PDF
Storz, J. F., B. A. Payseur, and M. W. Nachman. 2004. Genome scans of DNA variability in humans reveal evidence for selective sweeps outside of Africa. Molecular Biology and Evolution, 21: 1800-1811. PDF
Ramakrishnan, U., J. F. Storz, B. L. Taylor, and R. Lande. 2004. Estimation of genetically effective breeding numbers using a rejection algorithm approach. Molecular Ecology,13: 3283-3292. PDF
Storz, J. F., and J. M. Dubach. 2004. Natural selection drives altitudinal divergence at the albumin locus in deer mice, Peromyscus maniculatus. Evolution, 58: 1342-1352. PDF
Storz, J. F., and M. W. Nachman. 2003. Natural selection on protein polymorphism in the rodent genus Peromyscus: evidence from interlocus contrasts. Evolution, 57: 2628-2635. PDF
Storz, J. F. 2002. Contrasting patterns of divergence in quantitative traits and neutral DNA markers: analysis of clinal variation. Molecular Ecology, 11: 2537-2552. PDF
Storz, J. F., M. A. Beaumont, and S. C. Alberts. 2002. Genetic evidence for long-term population decline in a savannah-dwelling primate: inferences from a hierarchical Bayesian model. Molecular Biology and Evolution, 19: 1981-1990. PDF
Storz, J. F., U. Ramakrishnan, and S. C. Alberts. 2002. Genetic effective size of a wild primate population: influence of current and historical demography. Evolution, 56: 817-829. PDF
Storz, J. F., and M. A. Beaumont. 2002. Testing for genetic evidence of population expansion and contraction: an empirical analysis of microsatellite DNA variation using a hierarchical Bayesian model. Evolution, 56: 154-166. PDF
Storz, J. F., H. R. Bhat, and T. H. Kunz. 2001. Genetic consequences of polygyny and social structure in an Indian fruit bat, Cynopterus sphinx, I. Inbreeding, outbreeding, and population subdivision. Evolution, 55: 1215-1223. PDF
Storz, J. F., H. R. Bhat, and T. H. Kunz. 2001. Genetic consequences of polygyny and social structure in an Indian fruit bat, Cynopterus sphinx, II. Variance in male mating success and effective population size. Evolution, 55: 1224-1232. PDF
Storz, J. F., U. Ramakrishnan, and S. C. Alberts. 2001. Determinants of effective population size for loci with different modes of inheritance. Journal of Heredity, 92: 497-502. PDF
Storz, J. F., J. Balasingh, H. R. Bhat, P. T., Nathan, A. A. Prakash, D. P. Swami Doss, and T. H. Kunz. 2001. Clinal variation in body size and sexual dimorphism in an Indian fruit bat, Cynopterus sphinx (Chiroptera: Pteropodidae). Biological Journal of the Linnean Society, 72: 17-31. PDF
Storz, J. F. 2000. Variation at tri- and tetranucleotide repeat microsatellite loci in the fruit bat genus Cynopterus (Chiroptera: Pteropodidae). Molecular Ecology, 9: 1198-2200.
Storz, J. F., J. Balasingh, P. T. Nathan, K. Emmanuel, and T. H. Kunz. 2000. Dispersion and site-fidelity in a tent-roosting population of the short-nosed fruit bat (Cynopterus sphinx) in southern India. Journal of Tropical Ecology, 16: 117-131.
Storz, J. F., H. R. Bhat, and T. H. Kunz. 2000. Social structure of a polygynous tent-making bat, Cynopterus sphinx (Megachiroptera). Journal of Zoology (London), 251: 151-165.
Storz, J. F. 1999. Genetic consequences of mammalian social structure. Journal of Mammalogy, 80: 553-569.
Storz, J. F., and Kunz, T. H. 1999. Cynopterus sphinx. Mammalian Species, 613: 1-8.